Alopecia; neurotoxicity; leucopenia, neuritic pain, constipation; sensory loss, paraesthesia, difficulty in walking, slapping gait, loss of deep-tendon reflexes, muscle wasting; nausea, vomiting, diarrhoea, anorexia, stomatitis, oral ulceration, intestinal necrosis &/or perforation, abdominal cramps & distension; renal & urinary disorders; HTN, hypotension; neurological, endocrinal & haematological effects; depression, agitation, insomnia, hallucinations; transient cortical blindness, optic atrophy w/ blindness; oropharyngeal pain, acute resp distress syndrome, bronchospasm; fever, headache.